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Fungal Infections as an Uprising Threat to Human Health: Chemosensitization of Fungal Pathogens With AFP From Aspergillus giganteus.
Dhandapani K, Sivarajan K, Ravindhiran R, Sekar JN. Dhandapani K, et al. Front Cell Infect Microbiol. 2022 May 25;12:887971. doi: 10.3389/fcimb.2022.887971. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35694549 Free PMC article. Review.
Natural compounds including plant compounds and microbial proteins act as potential chemosensitizers to break the resistance in mycoses. Aspergillus giganteus, a filamentous fungus, is known to produce a cysteine rich extracellular protein called as antifungal prote …
Natural compounds including plant compounds and microbial proteins act as potential chemosensitizers to break the resistance in mycoses. …
Pharmacokinetic profile of sarcin and thionin from Aspergillus giganteus and in vitro validation against human fungal pathogen.
Ravindhiran R, Krishnamurthy R, Sivarajan K, Sekar JN, Chidambaram K, Alqahtani AM, Dhandapani K. Ravindhiran R, et al. Biosci Rep. 2022 Sep 30;42(9):BSR20220229. doi: 10.1042/BSR20220229. Biosci Rep. 2022. PMID: 35924795 Free PMC article.
The present study deals with the investigation of the mechanism of the active compounds from Aspergillus giganteus against aspergillosis. Primarily, the bioavailability and toxicological properties of antifungal proteins such as, sarcin, thionin, chitinase and their …
The present study deals with the investigation of the mechanism of the active compounds from Aspergillus giganteus against asp …
Confirmation of the Disulfide Connectivity and Strategies for Chemical Synthesis of the Four-Disulfide-Bond-Stabilized Aspergillus giganteus Antifungal Protein, AFP.
Váradi G, Batta G, Galgóczy L, Hajdu D, Fizil Á, Czajlik A, Virágh M, Kele Z, Meyer V, Jung S, Marx F, Tóth GK. Váradi G, et al. J Nat Prod. 2023 Apr 28;86(4):782-790. doi: 10.1021/acs.jnatprod.2c00954. Epub 2023 Feb 27. J Nat Prod. 2023. PMID: 36847642 Free PMC article.
Emerging fungal infections require new, more efficient antifungal agents and therapies. AFP, a protein from Aspergillus giganteus with four disulfide bonds, is a promising candidate because it selectively inhibits the growth of filamentous fungi. ...
Emerging fungal infections require new, more efficient antifungal agents and therapies. AFP, a protein from Aspergillus giganteus …
The Aspergillus giganteus antifungal protein AFPNN5353 activates the cell wall integrity pathway and perturbs calcium homeostasis.
Binder U, Bencina M, Eigentler A, Meyer V, Marx F. Binder U, et al. BMC Microbiol. 2011 Sep 23;11:209. doi: 10.1186/1471-2180-11-209. BMC Microbiol. 2011. PMID: 21943024 Free PMC article.
BACKGROUND: The antifungal protein AFPNN5353 is a defensin-like protein of Aspergillus giganteus. It belongs to a group of secretory proteins with low molecular mass, cationic character and a high content of cysteine residues. ...
BACKGROUND: The antifungal protein AFPNN5353 is a defensin-like protein of Aspergillus giganteus. It belongs to a group of sec …
Pectinase production by Aspergillus giganteus in solid-state fermentation: optimization, scale-up, biochemical characterization and its application in olive-oil extraction.
Ortiz GE, Ponce-Mora MC, Noseda DG, Cazabat G, Saravalli C, López MC, Gil GP, Blasco M, Albertó EO. Ortiz GE, et al. J Ind Microbiol Biotechnol. 2017 Feb;44(2):197-211. doi: 10.1007/s10295-016-1873-0. Epub 2016 Nov 22. J Ind Microbiol Biotechnol. 2017. PMID: 27878454
Consequently, new fungal strains able to produce higher pectinase titers are required. The aim of this work was to study the capability of Aspergillus giganteus NRRL10 to produce pectinolytic enzymes by SSF and evaluate the application of these in olive-oil extracti …
Consequently, new fungal strains able to produce higher pectinase titers are required. The aim of this work was to study the capability of …
Highly Oxygenated Constituents from a Marine Alga-Derived Fungus Aspergillus giganteus NTU967.
Chen JJ, Wang SW, Chiang YR, Pang KL, Kuo YH, Shih TY, Lee TH. Chen JJ, et al. Mar Drugs. 2020 Jun 6;18(6):303. doi: 10.3390/md18060303. Mar Drugs. 2020. PMID: 32517237 Free PMC article.
Agar-based disc diffusion antimicrobial assay has shown that the ethyl acetate extract of the fermented broth of Aspergillus giganteus NTU967 isolated from Ulva lactuca exhibited significant antimicrobial activity in our preliminary screening of bioactive fungal str …
Agar-based disc diffusion antimicrobial assay has shown that the ethyl acetate extract of the fermented broth of Aspergillus gigan …
Antifungal Peptides of the AFP Family Revisited: Are These Cannibal Toxins?
Meyer V, Jung S. Meyer V, et al. Microorganisms. 2018 Jun 2;6(2):50. doi: 10.3390/microorganisms6020050. Microorganisms. 2018. PMID: 29865265 Free PMC article. Review.
Of special interest is the exploitation of the AFP family of antimicrobial peptides, which include its founding member AFP from Aspergillus giganteus. This latter is a highly potent inhibitor of chitin synthesis and affects plasma membrane integrity in many human an …
Of special interest is the exploitation of the AFP family of antimicrobial peptides, which include its founding member AFP from Aspergill …
Biosynthesis of Low Molecular Weight Antifungal Protein from Aspergillus giganteus in Batch Fermentation and In-Vitro Assay.
Dutta D, Debnath DAS M. Dutta D, et al. Biocontrol Sci. 2018;23(2):41-51. doi: 10.4265/bio.23.41. Biocontrol Sci. 2018. PMID: 29910208 Free article.
Production of a new intracellular antifungal protein in submerged fermentation was optimized with yield of 0.980.1 mg/gram dry cell weight mycelia from Aspergillus giganteus MTCC 8408. The average molecular mass of the purified protein was figured as 5.122 kDa using …
Production of a new intracellular antifungal protein in submerged fermentation was optimized with yield of 0.980.1 mg/gram dry cell weight m …
Entomopathogenic effect of Aspergillus giganteus and Penicillium corylophilum on two triatomine vectors of Chagas disease.
da Costa GL, de Moraes AM, Galvão C. da Costa GL, et al. J Basic Microbiol. 2003;43(1):3-7. doi: 10.1002/jobm.200390003. J Basic Microbiol. 2003. PMID: 12596236
Two strains, Penicillium corylophilum and Aspergillus giganteus, of the most frequent species found in a survey of triatomines, were used for bioassays in the second and fourth nymphs stage of Triatoma infestans and Panstrongylus megistus. ...
Two strains, Penicillium corylophilum and Aspergillus giganteus, of the most frequent species found in a survey of triatomines …
The antifungal protein AFP from Aspergillus giganteus inhibits chitin synthesis in sensitive fungi.
Hagen S, Marx F, Ram AF, Meyer V. Hagen S, et al. Appl Environ Microbiol. 2007 Apr;73(7):2128-34. doi: 10.1128/AEM.02497-06. Epub 2007 Feb 2. Appl Environ Microbiol. 2007. PMID: 17277210 Free PMC article.
The antifungal protein AFP from Aspergillus giganteus is highly effective in restricting the growth of major human- and plant-pathogenic filamentous fungi. ...
The antifungal protein AFP from Aspergillus giganteus is highly effective in restricting the growth of major human- and plant- …
108 results